Timetable & learning outcomes

The program consists of 5 half-day sessions of distance training, and will propose interactive content. Alternating thematic and methodological interventions from internationally recognized speakers, learning outcomes of this summer school include:

› The latest in modern epidemiology of the most common neurological diseases
› In-depth description of innovative, high-dimensional MRI markers of brain aging in large population-based cohort studies
› Advanced brain imaging and novel “omics” tools, and their application in epidemiology of vascular and brain aging
› Large-scale genomic approaches (GWAS, Exome and Whole genome sequencing approaches), as well as epigenomics, proteomics, transcriptomics, and metabolomics approaches for neurological diseases
› Systems biology and translational approaches
› Single cell RNA sequencing
› Challenges and opportunities of planning new cohort studies and biobanks in the “omics” era
› Hands-on analysis and visualization of omics data and advanced brain imaging
› One-on-one collaboration with experts from around the world
› An editor’s guide for submitting papers on neuroepidemiology with large-scale imaging and omics data for peer reviewed journals
› Ethical considerations

Program

Please note: sessions will take place between 14:00 and 19:30 CEST each day. Lectures will be recorded for later viewing by summer school participants. Some self-guided work may be required throughout the summer school.

Monday October 11th, 2021
14:00 – 14:30		Welcome and introductions
14:30 – 15:30		Introduction to genomics of complex disorders: a short primer of GWAS and NGS	Anita DeStefano (USA), Chloe Sarnowski (USA)
15:40 – 16:40		Introduction to genomics of complex disorders: a short primer of GWAS and NGS	Anita DeStefano (USA), Chloe Sarnowski (USA)
16:40 - 17:10		Coffee break
17:10 – 19:00		Introduction to the epidemiology and clinical characteristics of dementia, stroke, Parkinson's disease	Lenore Launer (USA), Janika Kõrv (Estonia), Zuzana Koŝutzká (Slovakia)
Tuesday October 12th, 2021
14:00 – 14:50		Genomics of Alzheimer disease	Sudha Seshadri (USA)
15:00 - 16:05		Genomics of Stroke and MRI-markers of SVD / Stroke genomics in Africa	Stéphanie Debette (France), Rufus Akinyemi (Nigeria)
16:05 – 16:35		Coffee break
16:35 – 17:55		Introduction to population-based brain imaging	Tomáš Paus (Canada), Fabrice Crivello (France), Ami Tsuchida (France)
18:05 – 19:10		Genomics of large scale brain imaging markers (cortical thickness, subcortical volumes)	Edith Hofer (Austria), Claudia Satizabal (USA)
Wednesday October 13th, 2021
14:00 – 15:00		Introduction to epigenetics and epigenetics of vascular brain aging	Myriam Fornage (USA)
15:10 – 16:20		Technological innovation in metabolomics and metabolomics of brain aging	Zdenka Pausova (Canada)
16:20 – 16:50		Coffee break
16:50 – 17:50		Main principles polygenic risk prediction and Mendelian randomization	Aniket Mishra (France), Muralidharan Sargurupremraj (USA)
18:00 – 19:10		Proteomics and multiomics of brain and vascular disease	Carlos Cruchaga (USA)
Thursday October 14th, 2021
14:00 – 15:30		Large European and Asian biobanks and precision medicine	Lili Milani (Estonia), Yoichiro Kamatani (Japan)
15:40 – 16:10		Large population brain imaging initiatives	Paul Matthews (UK)
16:10 – 16:40		Coffee break
16:40 – 17:40		Integration of single cell and spatial transcriptomics in the study of mammalian development	Ioannis Ragoussis (Canada)
17:50 - 18:50		The single cell sequencing revolution for dissecting the biology of brain disease	Erik Boddeke (The Netherlands)
Friday October 15th, 2021
14:00 - 16:00		Participant project pitches
16:00 - 16:30		Coffee break
16:30 - 17:00		Epigenetics of Parkinson's disease	Tiago Outeiro (Germany)
17:10 - 18:10		"Neuroepidemiology" of SarsCOV2	Sudha Seshadri (USA)
18:20 - 19:20		Precision medicine and ethics	Janet Hart (USA)
19:30		Closing

A certificate of participation will be awarded to students upon completion of the course.